All it took was a hit song from Madonna - “4 Minutes” a.k.a. “4 Minutes to Save the World” - and a Miley Cyrus and Mandy Jiroux remake and a Madonna reply to the remake to generate millions of YouTube views. Watch all of the videos right here.

Miley Cyrus and Mandy Jiroux

Though it stars two best friends goofing off in front of a webcam in a bedroom, “The Miley and Mandy Show” is not exactly your typical YouTube channel. And not just because it stars the country’s highest-earning teen celeb, Miley Cyrus, and Mandy Jiroux, Miley’s backup dancer on the Best of Both Worlds Tour.

Miley Cyrus as Hannah Montana in concert, Orlando, February 2008

Their latest video, a high-flying dance video set to Madonna’s “4 Minutes,” appears to have prompted a YouTube response from the Material Girl herself.

The “Hannah Montana” star and her friend have been uploading a series of videos to the Web for the past two months, but none has garnered as much attention as last week’s, which has received over a million hits since it was uploaded on Sunday.

[…]

Not your typical cleaning lady, Madonna wears stiletto boots, a black dress and a long gold necklace as she vacuums what she says is the set of her new music video. Madge never actually says that her YouTube entry is a response to the Miley and Mandy creation, but she’s not fooling us.

“All you people out there who are making videos to my new single, ‘4 Minutes,’ keep up the good work, nice job,” she says in the video, before sternly offering some words of advice: “You’ve got to clean up after yourselves, all right? Because cleanliness is next to godliness.”

(Source: MTV: Miley Cyrus’ ‘4 Minutes’ Viral Video Gets A Reply From Madonna — Apparently)

Here is the “The Miley and Mandy Show” video - “M&M Cru with a U BATTLES Step Up 2″

Here is Madonna’s response: Madonna - Message to YouTube

Here is the original Madonna ft. Justin Timberlake - 4 Minutes video